Understanding the Entourage Effect

3 min read

Understanding the Entourage Effect

If you’ve been researching CBD, there’s a good chance that you’ve come across the term “entourage effect” before. CBD has the potential to be powerful on its own, but its therapeutic capabilities really shine when other cannabinoids and terpenes are present too.

Explaining the Entourage Effect

The entourage effect happens when the various compounds found in hemp work together to create a synergistic effect. That means CBD works alongside other cannabinoids like CBG, CBN, THC, THCa, and a wide array of terpenes, including bisabolene, farnesene, and guaiol, to provide powerful therapeutic effects for some.

Because the compounds in hemp can amplify each other’s chemistry, CBD products may be more effective when they contain more than just CBD alone. Products that contain only CBD without other cannabinoids or terpenes are known as Isolates. To understand why the entourage effect is worth seeking out, let’s break it down.

CBD and the other beneficial compounds in hemp target the endocannabinoid system, which scientists believe plays a critical role in your body’s well-being by maintaining several integral functions like mental health and wellness, mood, appetite, nutrient transport, energy storage, immune function, and the regulation of stress and pain perception.

Both the cannabinoids that your body produces and cannabinoids that come in through an external source – like hemp extract – target certain receptors within the endocannabinoid system. These are called the CB1 and CB2 receptors.

CB1 Receptors

CB₁ receptors can be found throughout the body and perform different tasks based on their location.

  • They may promote appetite.

  • They may help to regulate the buildup of body fat.

  • They may inhibit the overactive firing of nerve cells, helping to control conditions like epilepsy.

  • They may change the way you react to stressors and trauma.

  • They may provide relief from anxiety.

  • They may help moderate sensitivity to pain.

CB2 Receptors

CB₂ receptors can be found in the immune cells of organs such as the spleen, bone marrow, tonsils, and the digestive tract. The actions of CB₂ receptors correspond to their locations within the body.

  • They may reduce inflammation.

  • They may promote heart and bone health.

  • They may prevent or reduce nausea and vomiting.


Hemp also contains a wide array of terpenes that contribute their own benefits. Terpenes are the compounds that are responsible for the familiar smell that cannabis produces. Technically, terpenes are hydrocarbons, and they’re found in the essential oils of the plant.


Beta-caryophyllene is gastroprotective and provides strong anti-inflammatory properties. It also offers potential relief from anxiety and depression.


This terpene also serves as an anti-inflammatory agent and a hunger-suppressant and can even contribute to relief from discomfort.


Linalool has anticonvulsant and antibacterial properties and contributes to a feeling of relaxation.


Alpha-pinene is known for its energy-boosting and therapeutic properties, as well as improving focus and memory.


Bisabolol offers anti-irritant, anti-inflammatory, and antimicrobial properties.

The Entourage Effect at Work

When the chemical profile of hemp is left intact, researchers and consumers have discovered that the benefits are more than just the sum of its parts. While cannabinoids and terpenes each provide many layers of benefits alone, the benefits are multiplied when these compounds work together as nature intended.

Curious how you can benefit from the entourage effect? We recommend trying them for yourself to find your perfect balance. Check out our full and broad spectrum CBD wellness products created to help you feel your best, day in and day out.

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